You are here Researchers Prof. Francesco Cellesi Projects Podocyte-targeted Therapeutic Nanodelivery to Treat Proteinuric Glomerular Diseases

Podocyte-targeted Therapeutic Nanodelivery to Treat Proteinuric Glomerular Diseases

nanomateriali cellule renali

Project overview
This project aimed to develop novel nanotherapeutics for targeted delivery to the kidney glomerulus. Previous experimental results have demonstrated that all drugs which are currently used to treat or slow progression of kidney glomerular damage have a direct action on podocytes, the cells mainly responsible for glomerular filtration and primarily or secondarily involved in all proteinuric diseases. Therefore, the possibility to utilise a podocyte specific drug delivery could represent a major breakthrough in kidney disease research, particularly in terms of dosage reduction and elimination of systemic side effects of current therapies.

New engineered polymeric and lipidic nanocarriers were designed and produced with a fine tuning of key properties such as size, degradability, surface chemistry, drug loading and release. The effects of these nanomaterials on two-dimensional and three-dimensional cultures of glomerular cells were evaluated in vitro, in order to predict the effect of nanodelivery on glomerular filtration repair. Nanomaterial biodistribution, accumulation and permeability in the kidney glomerulus were assessed in animal models under physiological and pathological conditions. The next steps of this project will focus on testing the efficacy of these drug-loaded nanocarriers in vivo, comparing their effects with systemic administration of traditional drugs.

 


Principal Investigator
Prof. Francesco Cellesi  
          
Thematic area
Drug delivery; Theranostics

Duration and dates
31 months, 01.03.2013-30.10.2015

Financing institutions
Regione Lombardia through PAR-FSC funds

Co-funding institutions
CEN, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Politecnico di Milano

Project team
Francesco Cellesi, Maria Pia Rastaldi, Piergiorgio Messa, Maria Teresa Gandolfo, Simone Vettoretti, Stefania Ordanini, Maurizio Masi, Davide Moscatelli, Xiaoyi Huang, Li Min, Riccardo Bruni.

Project publications
Click here for Project publications and conferences list

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