You are here Researchers Prof. Francesca Baldelli Bombelli Projects Fluorine-functionalized theranostics in anti-cancer treatment

Fluorine-functionalized theranostics in anti-cancer treatment

Gruppo FBB Imaging 19F NPs










Project overview

In the course of this project we developed various fluorinated nanomaterials that may function at the same time as 19F-MRI (Magnetic Resonance Imaging) contrast agents and therapeutic tools for different diseases (theranostics). 19F-MRI may be advantageous in the field of Nanomedicine as the virtual absence of organic 19F in biological samples allows for highly sensitive in vivo detection (low background signal) also providing high body penetration. We engineered different typologies of fluorinated nanomaterials using both linear and branched fluorinated ligands obtaining nanoconstructs characterized by novel properties that can fit different biomedical applications. In particular, we developed a new 19F-MRI contrast agent, called PERFECTA, which displayed promising results for in vivo cell tracking and trafficking, as well as yielded different kinds of fluorinated nanoparticles for drug encapsulation and dual modality imaging. Overall, we believe that the novelty of our findings may be translated into different innovations in the fields of nanotechnology, nanomedicine, drug delivery, diagnostics, and oncology. 


Principal Investigator
Prof. Francesca Baldelli Bombelli
Thematic area
Multifunctional Nanoparticles for Theranostics

Duration and dates
tot. 30 mo.s, May 2013 – Oct. 2015

Financing institutions
Regione Lombardia through PAR-FSC funds

Co-funding institutions
CEN; Politecnico di Milano; Fondazione Politecnico di Milano

Project team
Francesca Baldelli Bombelli, Pierangelo Metrangolo, Gabriella Cavallo, Giancarlo Terraneo, Ilaria Tirotta, Valentina Dichiarante, Claudia Pigliacelli, Alessandro Monfredini, Elisa Salari, Monica Cesco.

Project publications
Click here for Project publications and conferences list


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